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Primary Antibodies

Cancer Diagnostics Solutions

A BCD E F G H I K L M N O P R S T U V W Z

IDH1

Clone: IDH1/7328
Description

Isocitrate dehydrogenases (IDHs) catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate, using either NAD? or NADP? as electron acceptors. Five isoforms have been identified: three NAD?-dependent forms localized to the mitochondrial matrix, and two NADP?-dependent isoforms?one mitochondrial and the other primarily cytosolic. The NADP?-dependent isozymes, including IDH1, function as homodimers. IDH1 is localized in the cytoplasm and peroxisomes and contains a PTS1 peroxisomal targeting sequence. In peroxisomes, it contributes to NADPH regeneration for redox reactions, such as the reduction of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs and the ?-hydroxylation of phytanic acid, which requires 2-oxoglutarate. In the cytoplasm, IDH1 plays a vital role in NADPH production, supporting lipid biosynthesis and cellular antioxidant defense. This antibody product is specific for the IDH1 R132H mutation, a common neomorphic mutation in gliomas and other cancers, which results in the production of the oncometabolite D-2-hydroxyglutarate, contributing to tumorigenesis.

Source:
Rabbit Monoclonal
Clone:
IDH1/7328
Application:
IHC
Isotype:
IgG, kappa
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Glioma tissue
Catalog No.
Volume/Qty.
Format
DH275-3R
3 ml
Ready to Use
DH275-6R
6 ml
Ready to Use
DH275-12R
12 ml
Ready to Use
DH275-01C
0.1 ml
Concentrated
DH275-05C
0.5 ml
Concentrated
DH275-1C
1 ml
Concentrated

IDH1 R132H

Clone: IHC132
Description

The IDH1 gene on chromosome 2q33.3 encodes for isocitrate dehydrogenase 1 (IDH1), located in the cytoplasm and the peroxisomes. This enzyme catalyzes NADPH production via oxidative decarboxylation of isocitrate to alpha-ketoglutarate in the Krebs citric acid cycle. Studies have shown that IDH1 mutation is an early step in gliomagenesis and has been reported to occur in grades II and III astrocytomas, oligodendrogliomas (OG), oligoastrocytomas (OA), and secondary GBM.

Mutations involving IDH1 occur in a high proportion of diffuse gliomas, with implications on diagnosis. About 90% involve exon 4 at codon 132, replacing amino acid arginine with histidine (R132H). Preliminary studies comparing Immunohistochemistry (IHC) with IDH1-R132H mutation-specific antibodies have shown concordance with DNA sequencing and no cross-reactivity with wild-type IDH1 or other mutant proteins.

Source:
Mouse Monoclonal
Clone:
IHC132
Application:
IHC
Isotype:
IgG1
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Glioma, Glioblastoma, Astrocytoma with IDH1 R132H Mutation
Catalog No.
Volume/Qty.
Format
DH171-3R
3 ml
Ready to Use
DH171-6R
6 ml
Ready to Use
DH171-12R
12 ml
Ready to Use
DH171-01C
0.1 ml
Concentrated
DH171-05C
0.5 ml
Concentrated
DH171-1C
1 ml
Concentrated

IDH1 R132H (Hu)

Clone: H09
Description

The monoclonal antibody clone H09 demonstrates high specificity for the isocitrate dehydrogenase 1 (IDH1) R132H point mutation in formalin-fixed, paraffin-embedded brain tumor specimens. Heterozygous substitutions at codon 132 of the IDH1 gene are frequently observed in World Health Organization (WHO) grade II and III diffuse gliomas. The IDH1 R132H mutation is present in approximately 70% of astrocytomas and oligodendroglial tumors. Owing to its high prevalence and tumor type?restricted distribution, this mutation provides a highly sensitive and specific diagnostic marker for distinguishing between tumor entities by immunohistochemistry, such as anaplastic astrocytoma versus primary glioblastoma, or diffuse astrocytoma (WHO grade II) versus pilocytic astrocytoma or ependymoma. Importantly, IDH1 R132H immunohistochemistry also facilitates differentiation between infiltrating tumor margins and reactive gliosis. The antibody is therefore of substantial diagnostic utility in both tumor classification and the detection of isolated infiltrating neoplastic cells. In routine neuropathological practice, the diagnostic workup of diffuse astrocytomas and oligodendrogliomas typically begins with immunohistochemical assessment of IDH1 R132H and ATRX expression.

Source:
Mouse Monoclonal
Clone:
H09
Application:
IHC
Isotype:
IgG2a
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Oligodendroglioma, diffuse astrocytoma
Catalog No.
Volume/Qty.
Format
DIA-H09-3R
3 ml
Ready to Use
DIA-H09-6R
6 ml
Ready to Use
DIA-H09-12R
12 ml
Ready to Use
DIA-H09-01C
0.1 ml
Concentrated
DIA-H09-05C
0.5 ml
Concentrated
DIA-H09-1C
1 ml
Concentrated

IDH2

Clone: GT673
Description

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes are divided into two distinct subclasses: one utilizes NAD as the electron acceptor, and the other utilizes NADP. Five isocitrate dehydrogenases have been identified three NAD-dependent isocitrate dehydrogenases localized in the mitochondrial matrix, and two NADP-dependent isocitrate dehydrogenases, with one being mitochondrial and the other predominantly cytosolic. Each NADP-dependent isozyme is a homodimer.

The protein encoded by this gene is the NADP-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production and may tightly associate or interact with the pyruvate dehydrogenase complex.

Source:
Mouse Monoclonal
Clone:
GT673
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Mitochondria
Positive Control:
HepG2, Jurkat, Raji
Catalog No.
Volume/Qty.
Format
DH336-3R
3 ml
Ready to Use
DH336-6R
6 ml
Ready to Use
DH336-12R
12 ml
Ready to Use
DH336-01C
0.1 ml
Concentrated
DH336-05C
0.5 ml
Concentrated
DH336-1C
1 ml
Concentrated

IgA

Clone: Polyclonal
Description

Immunoglobulin A (IgA) is a pivotal component of the mucosal immune system, serving as a primary defense mechanism at epithelial surfaces. It is abundantly present in mucosal secretions, including tears, saliva, colostrum, intestinal fluid, vaginal secretions, prostatic fluid, and respiratory tract secretions, where it provides protection against inhaled and ingested pathogens. Circulating IgA is also detectable in serum, albeit at lower concentrations. Secretory IgA demonstrates marked resistance to proteolytic degradation, enabling it to remain functional within physiologically harsh environments such as the gastrointestinal and respiratory tracts. This stability facilitates its protective role against microbial colonization and proliferation at mucosal surfaces. In clinical practice, IgA is of diagnostic significance, particularly in the evaluation of plasma cell dyscrasias such as multiple myeloma

Source:
Rabbit Polyclonal
Clone:
Polyclonal
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Tonsil
Catalog No.
Volume/Qty.
Format
DH550-3R
3 ml
Ready to Use
DH550-6R
6 ml
Ready to Use
DH550-12R
12 ml
Ready to Use
DH550-01C
0.1 ml
Concentrated
DH550-05C
0.5 ml
Concentrated
DH550-1C
1 ml
Concentrated

IgG4

Clone: IGHG4/2042
Description

The relatively constant sequences beyond the variable regions in immunoglobulins are called constant regions (C regions) and are found in both the heavy and light chains. Typically, the carbohydrate attachment sites on immunoglobulins are located in these C regions. Additionally, C regions help stabilize the structure by linking the variable regions through disulfide bonds. By increasing the rotation of the immunoglobulin arms, C regions aid in facilitating antigen interaction. Studies show that a significant number of patients with recurrent respiratory infections have low IgG4 levels.

IgG4-related sclerosing disease is now recognized as a systemic condition characterized by elevated serum IgG4 levels, sclerosing fibrosis, and extensive lymphoplasmacytic infiltration with numerous IgG4-positive plasma cells. IgG4 is commonly overexpressed in inflammatory pseudotumor (IPT) but underexpressed in inflammatory myofibroblastic tumor (IMT). Pulmonary nodular lymphoid hyperplasia (PNLH) is associated with an increased count of IgG4+ plasma cells

Source:
Rabbit Polyclonal
Clone:
IGHG4/2042
Application:
IHC
Isotype:
IgG, kappa
Tested Reactivity:
Human
Localization:
Membrane
Positive Control:
Tonsil
Catalog No.
Volume/Qty.
Format
DH288-3R
3 ml
Ready to Use
DH288-6R
6 ml
Ready to Use
DH288-12R
12 ml
Ready to Use
DH288-01C
0.1 ml
Concentrated
DH288-05C
0.5 ml
Concentrated
DH288-1C
1 ml
Concentrated

IgM

Clone: Polyclonal
Description

Immunoglobulin M (IgM) is initially expressed intracellularly during the early stages of B cell development (B lymphopoiesis). As B cells mature within the bone marrow, IgM is subsequently transported to the cell surface, where it is expressed as a membrane-bound form on immature and mature B cells, including those in the peripheral lymphoid compartments

Source:
Rabbit Polyclonal
Clone:
Polyclonal
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Tonsil
Catalog No.
Volume/Qty.
Format
DH453-3R
3 ml
Ready to Use
DH453-6R
6 ml
Ready to Use
DH453-12R
12 ml
Ready to Use
DH453-01C
0.1 ml
Concentrated
DH453-05C
0.5 ml
Concentrated
DH453-1C
1 ml
Concentrated

Immunoglobulin IgG

Clone: Polyclonal
Description

IgG, a monomeric immunoglobulin, is composed of two heavy and two light chains. It is the most prevalent immunoglobulin, making up 75% of serum immunoglobulin and is equally distributed in blood and tissues. It is the only iso type that can cross the placenta and bind to various pathogens, providing protection through complement activation, opsonisation, and toxin neutralization. There are four subclasses: IgG1 (66%), IgG2 (23%), IgG3 (7%), and IgG4 (4%).

IgG antibodies interact with surface immunoglobulin gamma chains and are useful in diagnosing leukaemia?s, plasmacytomas, and B-cell lineage Hodgkin?s lymphomas. These diseases often exhibit restricted heavy and light chain expression, making B-cell lymphomas detectable through clonal gene-rearrangement studies. Lupus nephritis, a kidney inflammation from systemic lupus erythematous, shows IgG, IgA, IgM, C3, and C1q in immunofluorescence. Clinically, it presents with haematuria and proteinuria, sometimes with nephrotic syndrome. Meningeal IgG glomerulonephritis, a newly recognized glomerulonephritis type, features meningeal dense deposits primarily positive for IgG on immunofluorescence

Source:
Rabbit Polyclonal
Clone:
Polyclonal
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Tonsil, Lymph Node, Kidney, Spleen
Catalog No.
Volume/Qty.
Format
DH328-3R
3 ml
Ready to Use
DH328-6R
6 ml
Ready to Use
DH328-12R
12 ml
Ready to Use
DH328-01C
0.1 ml
Concentrated
DH328-05C
0.5 ml
Concentrated
DH328-1C
1 ml
Concentrated

Inhibin Alpha

Clone: INHA/4265
Description

The inhibin ?-subunit dimerizes with either the ?A or ?B subunit to form inhibin A or inhibin B, respectively?both of which function as negative regulators of pituitary follicle-stimulating hormone (FSH) secretion. Inhibin plays a critical role in modulating gonadal stromal cell proliferation and has been identified as possessing tumor suppressor activity. Clinically, circulating levels of inhibin correlate with granulosa cell tumor burden, rendering it a useful biomarker for both primary diagnosis and monitoring of recurrent disease. In contrast, in prostate carcinoma, down regulation or silencing of the inhibin ?-subunit gene is observed, particularly in poorly differentiated tumor phenotypes. Given the differential expression patterns of inhibin across gonadal and extra gonadal tissues?often exhibiting tissue-specific and variable expression?it is hypothesized that inhibin functions both as a hormone and as a context-dependent growth and differentiation factor.

Source:
Mouse Monoclonal
Clone:
INHA/4265
Application:
IHC
Isotype:
IgG2a
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Adrenal Cortex and Testis
Catalog No.
Volume/Qty.
Format
DH172-3R
3 ml
Ready to Use
DH172-6R
6 ml
Ready to Use
DH172-12R
12 ml
Ready to Use
DH172-01C
0.1 ml
Concentrated
DH172-05C
0.5 ml
Concentrated
DH172-1C
1 ml
Concentrated

Inhibin Alpha

Clone: R1
Description

Inhibins are peptide hormones produced by the granulosa cells in female follicles and by Sertoli cells in the male seminiferous tubules. They are selectively expressed by cells of sex-cord stromal derivation, and inhibit the secretion of follitropin by the pituitary gland. Inhibin contains an alpha and beta subunit linked by disulfide bonds. Two forms of inhibin differ in their beta subunits (A or B), while their alpha subunits are identical. Inhibin belongs to the transforming growth factor-beta (TGF-beta) family. Inhibin Alpha antibody has demonstrated utility in differentiation between Adrenal Cortical Tumors and Renal Cell Carcinoma. Sex-Cord Stromal Tumors of the Ovary as well as Trophoblastic Tumors also demonstrate cytoplasmic positivity with this antibody

Source:
Mouse Monoclonal
Clone:
R1
Application:
IHC
Isotype:
IgG2a
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Adrenal Cortex, Placenta, Testis
Catalog No.
Volume/Qty.
Format
DH173-3R
3 ml
Ready to Use
DH173-6R
6 ml
Ready to Use
DH173-12R
12 ml
Ready to Use
DH173-01C
0.1 ml
Concentrated
DH173-05C
0.5 ml
Concentrated
DH173-1C
1 ml
Concentrated

INI-1

Clone: INI1/8851R/SMARCB1
Description

The INI-1 gene, which encodes a functionally uncharacterized protein component of the hSWI/SNF chromatin remodeling complex, is often mutated or deleted in malignant rhabdoid tumor (MRT). Two isoforms of INI-1 that differ by the variable inclusion of amino acids potentially are produced by differential RNA splicing.

Source:
Rabbit Monoclonal
Clone:
INI1/8851R/SMARCB1
Application:
IHC
Isotype:
IgG, kappa
Tested Reactivity:
Human
Localization:
Nucleus
Positive Control:
Astrocytoma or Kidney,Human Brain
Catalog No.
Volume/Qty.
Format
DH384-3R
3 ml
Ready to Use
DH384-6R
6 ml
Ready to Use
DH384-12R
12 ml
Ready to Use
DH384-01C
0.1 ml
Concentrated
DH384-05C
0.5 ml
Concentrated
DH384-1C
1 ml
Concentrated

INI1

Clone: A-5
Description

The anti-Ini1 antibody (clone A-5) is offered in unconjugated format as well as in multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and a range of Alexa Fluor? conjugates. Ini1, also referred to as SNF5 or SMARCB1, is a core component of the SWI/SNF (BAF) chromatin-remodeling complex, which plays a fundamental role in the regulation of gene expression. Through its integration into the complex, Ini1 facilitates ATP-dependent nucleosome remodeling, thereby promoting transcription factor accessibility to DNA regulatory elements. Together with other key subunits such as Brg1 and BAF155, Ini1 enhances the remodeling efficiency of the complex, underscoring its essential contribution to cellular differentiation and homeostasis. Aberrant expression or inactivation of SNF5 has been strongly associated with oncogenesis, most notably in malignant rhabdoid tumors, emphasizing its critical role in maintaining genomic integrity and proper control of cell proliferation.

Source:
Mouse Monoclonal
Clone:
A-5
Application:
IHC
Isotype:
IgG1, Kappa
Tested Reactivity:
Human
Localization:
Nucleus
Positive Control:
Tonsil, Kidney and Liver
Catalog No.
Volume/Qty.
Format
DH259-3R
3 ml
Ready to Use
DH259-6R
6 ml
Ready to Use
DH259-12R
12 ml
Ready to Use
DH259-01C
0.1 ml
Concentrated
DH259-05C
0.5 ml
Concentrated
DH259-1C
1 ml
Concentrated

INSM1

Clone: A8
Description

Insulinoma-associated protein 1 (INSM1) is a developmentally regulated zinc-finger transcription factor. It localizes to the nucleus and is expressed in embryonic issues undergoing neuroendocrine differentiation. INSM1 is not expressed in normal adult tissues but can be found highly expressed in neuroendocrine tumors. INSM1 is positive in 95% of lung small cell carcinoma and 91% of lung large cell neuroendocrine carcinoma, compared with 75% and 78% with the combined panel of traditional neuroendocrine markers (synaptophysin, chromogranin, and CD56). INSM1 stains 100% of the atypical carcinoids, typical carcinoids and paragangliomas, but only 3% of adenocarcinomas and 4% of squamous cell carcinomas. Therefore, INSM1 is sensitive and specific to be a single first-line pan-neuroendocrine marker

Source:
Mouse Monoclonal
Clone:
A8
Application:
IHC
Isotype:
IgG1, Kappa
Tested Reactivity:
Human
Localization:
Nucleus
Positive Control:
Neuroendocrine Tumor
Catalog No.
Volume/Qty.
Format
DH257-3R
3 ml
Ready to Use
DH257-6R
6 ml
Ready to Use
DH257-12R
12 ml
Ready to Use
DH257-01C
0.1 ml
Concentrated
DH257-05C
0.5 ml
Concentrated
DH257-1C
1 ml
Concentrated

Insulin

Clone: EP125
Description

Insulin is a peptide hormone that plays a central role in the regulation of glucose homeostasis. It enhances cellular uptake of monosaccharides, amino acids, and fatty acids by increasing membrane permeability, and it promotes key metabolic pathways including glycolysis, the pentose phosphate pathway, and hepatic glycogen synthesis. Insulin is synthesized and secreted by pancreatic ?-cells within the islets of Langerhans. Immunohistochemical detection using anti-insulin antibodies labels both normal and neoplastic insulin-secreting cells, and is diagnostically valuable in the identification of insulinomas.

Source:
Rabbit Monoclonal
Clone:
EP125
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Pancreas, Insulinoma
Catalog No.
Volume/Qty.
Format
DH424-3R
3 ml
Ready to Use
DH424-6R
6 ml
Ready to Use
DH424-12R
12 ml
Ready to Use
DH424-01C
0.1 ml
Concentrated
DH424-05C
0.5 ml
Concentrated
DH424-1C
1 ml
Concentrated
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