Primary Antibodies
Cancer Diagnostics Solutions
Desmin
Clone: D33
Description
Desmin is a type of intermediate filament found near the Z line in sarcomeres. Both vimentin and desmin are characteristics of mesenchymal cells.
Desmin antibody detects a protein that is expressed by cells of normal smooth, skeletal and cardiac muscles. Light microscopy studies of desmin suggest that it is primarily located at or near the periphery of Z lines in striated muscle fibrils. In smooth muscle, Desmin interconnects cytoplasmic dense bodies with membranebound dense plaques. Desmin antibody react with Leiomyomas, Rhabdomyomas, and Perivascular cells of Glomus Tumors of the skin (if they are of myogenic nature). This antibody is used to demonstrate the myogenic components/derivation of tumors.
Source:
Mouse Monoclonal
Clone:
D33
Application:
IHC
Isotype:
IgG1, Kappa
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Skeletal Muscle
Catalog No.
Volume/Qty.
Format
DH145-3R
3 ml
Ready to Use
DH145-6R
6 ml
Ready to Use
DH145-12R
12 ml
Ready to Use
DH145-01C
0.1 ml
Concentrated
DH145-05C
0.5 ml
Concentrated
DH145-1C
1 ml
Concentrated
DOG-1
Clone: DOG1.1
Description
DOG1, or Discovered on GIST-1, is an antibody widely utilized in immunohistochemistry (IHC) for the identification of gastrointestinal stromal tumors (GISTs). GISTs are mesenchymal tumors originating primarily in the stomach and small intestine, and the DOG1 antibody serves as a crucial diagnostic marker for these tumors. DOG1 is a protein encoded by the ANO1 gene, also known as TMEM16A, which functions as a calcium-activated chloride channel. The DOG1 antibody is specifically designed to target the DOG1 protein, exhibiting high sensitivity and specificity for GISTs. Its expression is observed in a vast majority of GISTs, including those that do not express KIT or CD34, other common markers for these tumors.
Source:
Mouse Monoclonal
Clone:
DOG1.1
Application:
IHC
Isotype:
IgG1, Kappa
Tested Reactivity:
Human
Localization:
Membrane
Positive Control:
Breast Carcinoma
Catalog No.
Volume/Qty.
Format
DH146-3R
3 ml
Ready to Use
DH146-6R
6 ml
Ready to Use
DH146-12R
12 ml
Ready to Use
DH146-01C
0.1 ml
Concentrated
DH146-05C
0.5 ml
Concentrated
DH146-1C
1 ml
Concentrated
DOG-1
Clone: EP332
Description
DOG1, "discovered on GIST 1" encodes for a protein of unknown function that is highly sensitive and specific for gastrointestinal stromal tumors (GIST). GISTs occur in bowel walls and are proposed to originate from the interstitial cells of Cajal. The majority of GISTs harbor activating mutations in KIT but approximately 5-15% of GIST are negative for c-Kit by immunohistochemistry, mainly associated with mutations in the PDGFRA gene.
Source:
Rabbit Monoclonal
Clone:
EP332
Application:
IHC
Isotype:
IgG1, Kappa
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Gastrointestinal stromal tumor (GIST)
Catalog No.
Volume/Qty.
Format
DH148-3R
3 ml
Ready to Use
DH148-6R
6 ml
Ready to Use
DH148-12R
12 ml
Ready to Use
DH148-01C
0.1 ml
Concentrated
DH148-05C
0.5 ml
Concentrated
DH148-1C
1 ml
Concentrated
Dystrophin
Clone: H-5
Description
Dystrophin is an essential cytoskeletal protein that anchors the actin cytoskeleton to the extracellular matrix through the dystrophin-glycoprotein complex (DGC), ensuring sarcolemmal stability and preserving muscle fiber integrity. Mutations or deletions in the dystrophin gene result in Duchenne and Becker muscular dystrophies. The dystrophin gene spans 2.4 Mb, contains over 80 exons, and produces a 14 kb mRNA regulated by multiple tissue-specific promoters and polyadenylation sites. Alternative splicing generates various isoforms with distinct tissue distributions. Although comprising only ~0.002% of total striated muscle protein, dystrophin is enriched at triadic junctions, contributing to calcium homeostasis and mechanical force transmission during muscle contraction.
Source:
Mouse Monoclonal
Clone:
H-5
Application:
IHC
Isotype:
IgG2b
Tested Reactivity:
Human
Localization:
Membrane
Positive Control:
human skeletal muscle
Catalog No.
Volume/Qty.
Format
DH432-3R
3 ml
Ready to Use
DH432-6R
6 ml
Ready to Use
DH432-12R
12 ml
Ready to Use
DH432-01C
0.1 ml
Concentrated
DH432-05C
0.5 ml
Concentrated
DH432-1C
1 ml
Concentrated
Dystrophin
Clone: DY8/6C5
Description
Dystrophin, the protein encoded by the Duchene and Becker muscular dystrophy (DMD/BMD) gene, exhibits a relative molecular mass of approximately 400 kDa. Immunohistochemical analysis using anti-dystrophin antibodies reveals that individuals affected by DMD exhibit a complete absence or markedly reduced levels of dystrophin in muscle fibers. In contrast, BMD patients express dystrophin of diminished quantity and/or aberrant molecular size. The monoclonal antibody utilized in this analysis specifically targets an epitope located within the central rod domain of dystrophin, encompassing amino acid residues 1181 to 1388. Immunodetection of dystrophin is a valuable diagnostic tool for differentiating DMD and BMD from other neuromuscular disorders
Source:
Mouse Monoclonal
Clone:
DY8/6C5
Application:
IHC
Isotype:
IgG1
Tested Reactivity:
Human
Localization:
Membrane
Positive Control:
Breast Carcinoma
Catalog No.
Volume/Qty.
Format
DH149-3R
3 ml
Ready to Use
DH149-6R
6 ml
Ready to Use
DH149-12R
12 ml
Ready to Use
DH149-01C
0.1 ml
Concentrated
DH149-05C
0.5 ml
Concentrated
DH149-1C
1 ml
Concentrated
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