Primary Antibodies
Cancer Diagnostics Solutions
Factor VIII Related Antigen
Clone: 3E2D10
Description
Von Willebrand Factor (vWF) is a large multimeric glycoprotein localized to endothelial cells, circulating plasma, and platelet ?-granules. It functions as a carrier for coagulation Factor VIII and facilitates platelet adhesion and aggregation at sites of vascular injury. VWF undergoes multiple posttranslational modifications including propeptide cleavage and N-terminal disulfide bond formation that modulate its conformation, multimeric assembly, and binding affinity for Factor VIII. Immunohistochemical detection of vWF is utilized to confirm endothelial cell lineage in lesions of ambiguous histogenesis, such as Kaposi sarcoma and cardiac myxoma. It is commonly employed within a panel of vascular markers to distinguish vascular neoplasms from those of non-vascular origin. However, vWF expression is not uniformly retained in all endothelial-derived tumors
Source:
Mouse Monoclonal
Clone:
3E2D10
Application:
IHC
Isotype:
IgG1, Kappa
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Human tonsil
Catalog No.
Volume/Qty.
Format
DH157-3R
3 ml
Ready to Use
DH157-6R
6 ml
Ready to Use
DH157-12R
12 ml
Ready to Use
DH157-01C
0.1 ml
Concentrated
DH157-05C
0.5 ml
Concentrated
DH157-1C
1 ml
Concentrated
Factor XIIIa
Clone: F13A1/1448
Description
Factor XIIIa is a plasma transglutaminase integral to the blood coagulation cascade, crucial for stabilizing fibrin networks at injury sites to form clots.
Source:
Mouse Monoclonal
Clone:
F13A1/1448
Application:
IHC
Isotype:
IgG1, Kappa
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Dermatofibroma
Catalog No.
Volume/Qty.
Format
DH380-3R
3 ml
Ready to Use
DH380-6R
6 ml
Ready to Use
DH380-12R
12 ml
Ready to Use
DH380-01C
0.1 ml
Concentrated
DH380-05C
0.5 ml
Concentrated
DH380-1C
1 ml
Concentrated
Factor XIIIa
Clone: AC-1A1
Description
Factor XIIIa is a plasma transglutaminase integral to the blood coagulation cascade, crucial for stabilizing fibrin networks at injury sites to form clots. It is expressed in platelets, megakaryocytes, fibroblast-like cells of the placenta, uterus, and prostate, as well as in monocytes, macrophages, and dermal dendritic cells. Anti-Factor XIIIa immunohistochemistry is employed to identify fibrohistiocytic neoplasms, such as dermatofibromas.
Source:
Mouse Monoclonal
Clone:
AC-1A1
Application:
IHC
Isotype:
IgG1, Kappa
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Dermatofibroma
Catalog No.
Volume/Qty.
Format
DH306-3R
3 ml
Ready to Use
DH306-6R
6 ml
Ready to Use
DH306-12R
12 ml
Ready to Use
DH306-01C
0.1 ml
Concentrated
DH306-05C
0.5 ml
Concentrated
DH306-1C
1 ml
Concentrated
Factors VIII-Related Antigen
Clone: Polyclonal
Description
Factor VIII?related antigen, also known as von Willebrand factor (vWF), is a high-molecular-weight glycoprotein that plays a critical role in primary hemostasis by mediating platelet adhesion to exposed subendothelial matrix components at sites of vascular injury. Immunoreactivity for anti?Factor VIII?related antigen is characteristically observed in vascular endothelial cells and benign vascular proliferations such as hemangiomas, as well as in most neoplasms of endothelial lineage, including Kaposi?s sarcoma and angiosarcoma.
Source:
Rabbit Polyclonal
Clone:
Polyclonal
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Placenta
Catalog No.
Volume/Qty.
Format
DH598-3R
3 ml
Ready to Use
DH598-6R
6 ml
Ready to Use
DH598-12R
12 ml
Ready to Use
DH598-01C
0.1 ml
Concentrated
DH598-05C
0.5 ml
Concentrated
DH598-1C
1 ml
Concentrated
Fascin
Clone: 55-k2
Description
Fascin is a 55-kDa actin-bundling protein that plays a critical role in the regulation of cell migration. It is frequently upregulated in a wide range of human carcinomas, where its overexpression has been associated with enhanced metastatic potential. Fascin demonstrates high sensitivity in labeling Reed?Sternberg cells, making it a valuable diagnostic marker for classical Hodgkin?s lymphoma
Source:
Mouse Monoclonal
Clone:
55-k2
Application:
IHC
Isotype:
IgG1
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Hodgkin's lymphoma
Catalog No.
Volume/Qty.
Format
DH429-3R
3 ml
Ready to Use
DH429-6R
6 ml
Ready to Use
DH429-12R
12 ml
Ready to Use
DH429-01C
0.1 ml
Concentrated
DH429-05C
0.5 ml
Concentrated
DH429-1C
1 ml
Concentrated
Filamin A
Clone: Polyclonal
Description
Filamin A is an actin-crosslinking cytoskeletal protein that generates flexible, V-shaped bridges between adjacent actin filaments. It consists of two identical polypeptide subunits that dimerize at their C-terminal ends, while each N-terminal region contains a conserved actin-binding domain. Filamin A is widely expressed across multiple human cell types, including platelets, lymphocytes, fibroblasts, and smooth muscle cells, where it contributes to cytoskeletal organization, mechanotransduction, and cell motility.
Source:
Rabbit Polyclonal
Clone:
Polyclonal
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Human Colon Carcinoma
Catalog No.
Volume/Qty.
Format
DH587-3R
3 ml
Ready to Use
DH587-6R
6 ml
Ready to Use
DH587-12R
12 ml
Ready to Use
DH587-01C
0.1 ml
Concentrated
DH587-05C
0.5 ml
Concentrated
DH587-1C
1 ml
Concentrated
Fli-1
Clone: G146-22
Description
Friend leukemia integration 1 (Fli-1) is a member of the ETS family of sequence-specific DNA-binding transcription factors and plays a critical role in the regulation of cellular proliferation, differentiation, and oncogenic transformation. In approximately 90% of Ewing sarcoma/primitive neuroectodermal tumors (ES/PNET), a characteristic chromosomal translocation, t(11;22)(q24;q12), leads to fusion of the EWSR1 gene with FLI1, resulting in expression of the oncogenic EWS?FLI-1 fusion protein, which is reliably detectable by Fli-1?specific antibodies.In normal tissues, Fli-1 expression is largely restricted to endothelial cells and a subset of small lymphocytes. In contrast, Fli-1 is expressed in the vast majority of vascular neoplasms, including angiosarcomas, hemangioendotheliomas, hemangiomas, and Kaposi sarcoma. Comparative studies have demonstrated that Fli-1 immunoreactivity exhibits sensitivity and specificity comparable to or exceeding that of established endothelial markers such as CD31, CD34, and factor VIII?related antigen.Notably, Fli-1 represents the first endothelial marker with predominant nuclear localization, as opposed to cytoplasmic or membranous expression. This nuclear staining pattern minimizes background and cytoplasmic artifacts commonly associated with endogenous peroxidase or biotin activity, thereby enhancing the interpretive reliability of immunohistochemical analyses.
Source:
Mouse Monoclonal
Clone:
G146-22
Application:
IHC
Isotype:
IgG2b
Tested Reactivity:
Human
Localization:
Nuclear
Positive Control:
Adrenal Gland, Fallopian Tube
Catalog No.
Volume/Qty.
Format
DH602-3R
3 ml
Ready to Use
DH602-6R
6 ml
Ready to Use
DH602-12R
12 ml
Ready to Use
DH602-01C
0.1 ml
Concentrated
DH602-05C
0.5 ml
Concentrated
DH602-1C
1 ml
Concentrated
FLI-1
Clone: MRQ-1
Description
Friend leukemia integration 1 transcription factor (FLI-1) is a protein encoded by the proto-oncogene FLI-1. The FLI-1 protein plays a critical role in the pathogenesis of Ewing sarcoma/peripheral primitive neuroectodermal tumor (ES/pPNET). Normally, FLI-1 is expressed in endothelial cells and hematopoietic cells, including T-lymphocytes. Immunohistochemical detection of the FLI-1 protein has proven valuable in distinguishing ES/pPNET from most of its potential mimics. ES/pPNET is a rare primary tumor of the bone and soft tissue that resembles other undifferentiated tumors.
Source:
Mouse Monoclonal
Clone:
MRQ-1
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Nucleus
Positive Control:
Primitive neuroectodermal tumor
Catalog No.
Volume/Qty.
Format
DH307-3R
3 ml
Ready to Use
DH307-6R
6 ml
Ready to Use
DH307-12R
12 ml
Ready to Use
DH307-01C
0.1 ml
Concentrated
DH307-05C
0.5 ml
Concentrated
DH307-1C
1 ml
Concentrated
FOXA1
Clone: EP277
Description
FOXA1, also referred to as hepatocyte nuclear factor 3-alpha, belongs to the forkhead box (FOX) family of transcription factors. It was originally identified as a hepatocyte-enriched regulator essential for the transcription of genes such as transthyretin and ?1-antitrypsin. More recently, FOXA1 has been recognized as a critical modulator of estrogen receptor (ER) signaling and endocrine responsiveness in breast carcinoma. Its expression shows strong correlation with ER positivity, particularly within luminal A subtype breast cancers, a molecular phenotype associated with favorable clinical outcomes.
Source:
Rabbit Monoclonal
Clone:
EP277
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Nucleus
Positive Control:
Breast Carcinoma
Catalog No.
Volume/Qty.
Format
DH305-3R
3 ml
Ready to Use
DH305-6R
6 ml
Ready to Use
DH305-12R
12 ml
Ready to Use
DH305-01C
0.1 ml
Concentrated
DH305-05C
0.5 ml
Concentrated
DH305-1C
1 ml
Concentrated
FOXL2
Clone: FOXL2/8701R
Description
FOXL2 is a lineage-defining transcription factor that plays an essential role in ovarian differentiation, maintenance of ovarian identity, and active repression of the somatic testicular differentiation program. It preserves granulosa cell fate and prevents ovarian-to-testicular transdifferentiation through direct transcriptional repression of the Sertoli cell?determining gene SOX9.
Physiologic FOXL2 expression is predominantly restricted to ovarian tissue and the parathyroid gland, and it is characteristically retained in sex cord?stromal neoplasms. In diagnostic surgical pathology, FOXL2 is routinely employed as an immunohistochemical marker of sex cord?stromal differentiation, in conjunction with inhibin, calretinin, and steroidogenic factor-1 (SF-1), to support tumor classification and lineage assignment.
Source:
Rabbit Monoclonal
Clone:
FOXL2/8701R
Application:
IHC
Isotype:
IgG / Kappa
Tested Reactivity:
Human
Localization:
Nuclear
Positive Control:
Ovarian follicular and stromal cells.
Catalog No.
Volume/Qty.
Format
DH620-3R
3 ml
Ready to Use
DH620-6R
6 ml
Ready to Use
DH620-12R
12 ml
Ready to Use
DH620-01C
0.1 ml
Concentrated
DH620-05C
0.5 ml
Concentrated
DH620-1C
1 ml
Concentrated
FOXP3
Clone: EP340
Description
FOXP3, also referred to as scurfin, is a transcription factor belonging to the forkhead/winged-helix family of proteins and plays a pivotal role in the development, maintenance, and suppressive function of regulatory T cells (Tregs). In Treg-specific cellular models, FOXP3 binds to the promoter regions of numerous genes essential for Treg-mediated immunoregulatory functions and can act as a transcriptional repressor upon T cell receptor (TCR) engagement.
Dysregulation in the frequency or function of FOXP3-expressing Tregs has been associated with various pathological conditions. In the tumor microenvironment, there is often a relative enrichment of FOXP3+ regulatory T cells, which contributes to an immunosuppressive milieu that facilitates immune evasion by malignant cells.
Source:
Rabbit Monoclonal
Clone:
EP340
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Nucleus
Positive Control:
Tonsil, Lymph Node, Thymus
Catalog No.
Volume/Qty.
Format
DH486-3R
3 ml
Ready to Use
DH486-6R
6 ml
Ready to Use
DH486-12R
12 ml
Ready to Use
DH486-01C
0.1 ml
Concentrated
DH486-05C
0.5 ml
Concentrated
DH486-1C
1 ml
Concentrated
FSH
Clone: EP257
Description
Follicle-stimulating hormone (FSH) is a hormone produced and released by gonadotropic cells in the anterior pituitary gland. In females, FSH promotes the maturation of immature ovarian follicles, aiding in their development to a mature state. As the follicle matures, it secretes inhibin, which in turn reduces FSH production. In males, FSH stimulates the Sertoli cells in the testes to produce androgen-binding protein, playing a vital role in sperm production (spermatogenesis). FSH and luteinizing hormone (LH) work together to support reproductive processes.
FSH antibodies are valuable markers for classifying pituitary tumors and studying pituitary-related diseases, as they specifically react with cells that produce FSH.
Source:
Rabbit Monoclonal
Clone:
EP257
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Pituitary
Catalog No.
Volume/Qty.
Format
DH343-3R
3 ml
Ready to Use
DH343-6R
6 ml
Ready to Use
DH343-12R
12 ml
Ready to Use
DH343-01C
0.1 ml
Concentrated
DH343-05C
0.5 ml
Concentrated
DH343-1C
1 ml
Concentrated
FSH-Beta
Clone: FSHb/1062
Description
Human follicle-stimulating hormone (hFSH) is a glycoprotein hormone with a molecular mass of approximately 35.5 kDa, commonly purified from the urine of postmenopausal women. It functions as a heterodimer composed of two non-covalently associated subunits: a 165-amino acid alpha (?) subunit, which is common among glycoprotein hormones and biologically inactive on its own, and a hormone-specific beta (?) subunit consisting of 115 amino acids, which confers biological specificity and receptor-binding activity
Source:
Mouse Monoclonal
Clone:
FSHb/1062
Application:
IHC
Isotype:
IgG1, Kappa
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Anterior Pituitary
Catalog No.
Volume/Qty.
Format
DH448-3R
3 ml
Ready to Use
DH448-6R
6 ml
Ready to Use
DH448-12R
12 ml
Ready to Use
DH448-01C
0.1 ml
Concentrated
DH448-05C
0.5 ml
Concentrated
DH448-1C
1 ml
Concentrated
FUMARATE HYDRATASE
Clone: ZR458
Description
Fumarate Hydratase (FH), also known as fumarase, is a mitochondrial enzyme integral to the tricarboxylic acid (TCA) cycle, catalyzing the reversible conversion of fumarate to malate. Immunohistochemically, FH exhibits strong expression in mitochondria-rich normal tissues such as renal and hepatic parenchyma. Germline pathogenic variants in the FH gene are causative of Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC), a cancer predisposition syndrome characterized by cutaneous and uterine leiomyomas and a highly aggressive form of renal cell carcinoma. FH deficiency in tumors can be assessed by immunohistochemistry, serving as a diagnostic tool in HLRCC-associated neoplasms. FH-deficient pheochromocytomas (PCCs) and paragangliomas (PGLs), although underrecognized, can be reliably identified via loss of FH expression on IHC. These neoplasms are strongly associated with germline missense mutations in FH, yet they are rarely accompanied by leiomyomas or renal cell carcinoma, indicating a possible genotype-phenotype correlation. Emerging evidence suggests that FH-deficient PCCs/PGLs may carry an elevated risk of metastatic progression.
Source:
Rabbit Monoclonal
Clone:
ZR458
Application:
IHC
Isotype:
IgG2b, kappa
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Normal kidney
Catalog No.
Volume/Qty.
Format
DH428-3R
3 ml
Ready to Use
DH428-6R
6 ml
Ready to Use
DH428-12R
12 ml
Ready to Use
DH428-01C
0.1 ml
Concentrated
DH428-05C
0.5 ml
Concentrated
DH428-1C
1 ml
Concentrated
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