×

Primary Antibodies

Cancer Diagnostics Solutions

A BCD E F G H I K L M N O P R S T U V W Z

E-Cadherin

Clone: EP6
Description

Cadherins are a class of transmembrane proteins. They play an important role in cell adhesion by ensuring cells within tissues are bound together. E-Cadherin is an adhesion protein that is expressed in cells of epithelial lineage. It stains positively in glandular epithelium as well as Adenocarcinomas of the lung and G.I. tract, and ovary.

E-Cadherin has been useful in distinguishing Adenocarcinoma from Mesothelioma. It has also been shown to be positive in some Thyroid Carcinomas. It can be used to differentiate Ductal Carcinomas (positive for E-Cadherin) from Lobular Breast Carcinomas.

Source:
Rabbit Monoclonal
Clone:
EP6
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Membrane
Positive Control:
Breast Carcinoma, Colon, Cervix, Pancreas, Lung, Ovary, GI Tract
Catalog No.
Volume/Qty.
Format
DH150-3R
3 ml
Ready to Use
DH150-6R
6 ml
Ready to Use
DH150-12R
12 ml
Ready to Use
DH150-01C
0.1 ml
Concentrated
DH150-05C
0.5 ml
Concentrated
DH150-1C
1 ml
Concentrated

EBV-LMP

Clone: EBV/12703R
Description

This antibody is specific to 60kDa latent membrane protein (LMP-1) encoded by the BNLF1 gene of the EBV. This antibody stains strongly with EBV-positive lymphoblastoid cell lines and EBV infected B cell immunoblasts in infectious mononucleosis.

EBV, also designated human herpesvirus 4 (HHV-4), is a member of the herpesvirus family and is one of the most common human viruses. EBV infects B cells and, though often asymptomatic, it can cause infectious mononucleosis, a disease characterized by fatigue, fever, sore throat and muscle soreness

Source:
Rabbit Monoclonal
Clone:
EBV/12703R
Application:
IHC
Isotype:
IgG, kappa
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
EBV infected Tissues
Catalog No.
Volume/Qty.
Format
DH377-3R
3 ml
Ready to Use
DH377-6R
6 ml
Ready to Use
DH377-12R
12 ml
Ready to Use
DH377-01C
0.1 ml
Concentrated
DH377-05C
0.5 ml
Concentrated
DH377-1C
1 ml
Concentrated

EBV-LMP

Clone: CS1-4
Description

This antibody is a mixture of four different monoclonal antibodies. This antibody is specific to 60kDa latent membrane protein (LMP-1) encoded by the BNLF1 gene of the EBV. Each clone reacts with different epitopes on the hydrophilic C-terminus of the cytoplasmic domain of LMP-1.

This antibody stains strongly with EBV-positive lymphoblastoid cell lines and EBV infected B cell immunoblasts in infectious mononucleosis. EBV, also designated human herpesvirus 4 (HHV-4), is a member of the herpesvirus family and is one of the most common human viruses. EBV infects B cells and, though often asymptomatic, it can cause infectious mononucleosis, a disease characterized by fatigue, fever, sore throat and muscle soreness.

Source:
Mouse Monoclonal
Clone:
CS1-4
Application:
IHC
Isotype:
IgG1, Kappa
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
EBV infected Tissues
Catalog No.
Volume/Qty.
Format
DH298-3R
3 ml
Ready to Use
DH298-6R
6 ml
Ready to Use
DH298-12R
12 ml
Ready to Use
DH298-01C
0.1 ml
Concentrated
DH298-05C
0.5 ml
Concentrated
DH298-1C
1 ml
Concentrated

EGFR

Clone: EGFR/9166R
Description

EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factora (TGFa), Heparin binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin.

Source:
Rabbit Monoclonal
Clone:
EGFR/9166R
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Membrane
Positive Control:
Lung adenocarcinoma
Catalog No.
Volume/Qty.
Format
DH378-3R
3 ml
Ready to Use
DH378-6R
6 ml
Ready to Use
DH378-12R
12 ml
Ready to Use
DH378-01C
0.1 ml
Concentrated
DH378-05C
0.5 ml
Concentrated
DH378-1C
1 ml
Concentrated

EGFR

Clone: EP22
Description

EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factora (TGFa), Heparin binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin.

EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

Source:
Rabbit Monoclonal
Clone:
EP22
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Membrane
Positive Control:
Lung adenocarcinoma
Catalog No.
Volume/Qty.
Format
DH151-3R
3 ml
Ready to Use
DH151-6R
6 ml
Ready to Use
DH151-12R
12 ml
Ready to Use
DH151-01C
0.1 ml
Concentrated
DH151-05C
0.5 ml
Concentrated
DH151-1C
1 ml
Concentrated

EGFR

Clone: Polyclonal
Description

The epidermal growth factor receptor (EGFR) is a transmembrane receptor tyrosine kinase belonging to the ErbB/HER family, which also includes ERBB2 (HER2), ERBB3, and ERBB4. It is encoded by the EGFR gene located on chromosome 7p11.2. EGFR is activated upon ligand binding primarily epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-? to its extracellular domain, which induces receptor dimerization and subsequent auto phosphorylation of specific tyrosine residues within the cytoplasmic domain. This phosphorylation event initiates downstream signaling cascades involved in cell proliferation, survival, angiogenesis, and migration. Dysregulation of EGFR, particularly through gene amplification or protein overexpression, has been implicated in the pathogenesis of a wide spectrum of malignancies, including those of the head and neck, brain, lung, bladder, breast, stomach, oesophagus, endometrium, cervix, vulva, and ovary, with a strong association seen in squamous cell carcinomas. EGFR serves as a critical therapeutic target for both monoclonal antibodies and small molecule tyrosine kinase inhibitors in cancer treatment.

Source:
Rabbit Polyclonal
Clone:
Polyclonal
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Membrane
Positive Control:
Skin, Placenta
Catalog No.
Volume/Qty.
Format
DH152-3R
3 ml
Ready to Use
DH152-6R
6 ml
Ready to Use
DH152-12R
12 ml
Ready to Use
DH152-01C
0.1 ml
Concentrated
DH152-05C
0.5 ml
Concentrated
DH152-1C
1 ml
Concentrated

EMA (Epithelial Membrane Antigen)

Clone: E29
Description

Antibodies against DOG1 have been shown to be highly sensitive and specific, demonstrating 98-100% reactivity to GIST. DOG1 staining pattern is cytoplasmic and membranous, staining tumor cells and interstitial cells of Cajal. Its sensitivity was deemed superior to c-Kit in that many cases with PDGFRA mutations that failed to show c-kit reactivity were DOG-1 positive.

Source:
Mouse Monoclonal
Clone:
E29
Application:
IHC
Isotype:
IgG2a,Kappa
Tested Reactivity:
Human
Localization:
Cytolasm, Membrane
Positive Control:
Breast, Skin, Colon, Kidney, Cervix
Catalog No.
Volume/Qty.
Format
DH153-3R
3 ml
Ready to Use
DH153-6R
6 ml
Ready to Use
DH153-12R
12 ml
Ready to Use
DH153-01C
0.1 ml
Concentrated
DH153-05C
0.5 ml
Concentrated
DH153-1C
1 ml
Concentrated

EPCAM

Clone: Ber-EP4
Description

Recognizes a 40-43kDa transmembrane epithelial glycoprotein, identified as epithelial specific antigen (ESA), or epithelial cellular adhesion molecule (Ep-CAM). It is expressed on baso-lateral cell surface in most simple epithelia and a vast majority of carcinomas with the exception of adult squamous epithelium, hepatocytes and gastric epithelial cells. This antibody has been used to distinguish adenocarcinoma from pleural mesothelioma and hepatocellular carcinoma. It is also useful in distinguishing serous carcinomas of the ovary from mesothelioma. It has been reported that this epithelial antigen plays an important role as a tumor-cell marker in lymph nodes from patients with esophageal carcinoma otherwise classified as node-negative. Epithelial antigen has also been suggested as a discriminator between basal cell and baso-squamous carcinomas, and squamous cell carcinoma of the skin.

Source:
Mouse Monoclonal
Clone:
Ber-EP4
Application:
IHC
Isotype:
IgG1, Kappa
Tested Reactivity:
Human
Localization:
Membrane
Positive Control:
Breast Tumor
Catalog No.
Volume/Qty.
Format
DH337-3R
3 ml
Ready to Use
DH337-6R
6 ml
Ready to Use
DH337-12R
12 ml
Ready to Use
DH337-01C
0.1 ml
Concentrated
DH337-05C
0.5 ml
Concentrated
DH337-1C
1 ml
Concentrated

EPCAM/CD326

Clone: EP155
Description

Ep-CAM (epithelial cell adhesion molecule), also known as epithelial-specific antigen (ESA), is a 40 kDa transmembrane glycoprotein predominantly expressed in epithelial tissues. It functions as a calcium-independent, homotypic adhesion molecule and exerts regulatory effects on epithelial cell proliferation, differentiation, and metabolism. Ep-CAM promotes rapid induction of proto-oncogene c-myc and cell cycle regulators such as cyclins A and E, thereby influencing cell cycle progression. Adhesions mediated by Ep-CAM negatively modulate cadherin-dependent cell?cell junctions, which can alter epithelial architecture and growth dynamics. Overexpression of Ep-CAM has been associated with increased epithelial cell proliferation and malignant transformation. It is widely expressed in human carcinomas and serves as a diagnostic marker of epithelial lineage tumors. Ep-CAM is localized to the basolateral membrane of most simple epithelia and is expressed across multiple carcinoma subtypes. Importantly, it has been reported to aid in distinguishing adenocarcinomas from malignant pleural mesotheliomas

Source:
Rabbit Monoclonal
Clone:
EP155
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Membrane
Positive Control:
Breast carcinoma
Catalog No.
Volume/Qty.
Format
DH379-3R
3 ml
Ready to Use
DH379-6R
6 ml
Ready to Use
DH379-12R
12 ml
Ready to Use
DH379-01C
0.1 ml
Concentrated
DH379-05C
0.5 ml
Concentrated
DH379-1C
1 ml
Concentrated

ER Beta

Clone: ERb455
Description

Estrogen Receptor beta (ER?; NR3A2) is a nuclear receptor protein with an approximate molecular weight of 55 kDa, though multiple isoforms ranging from 36 to 59 kDa have been identified. Human ER? was initially cloned from testicular tissue. Estrogen receptors (ERs) belong to the steroid/thyroid hormone receptor superfamily of ligand-dependent nuclear transcription factors. Upon binding to estrogens, ERs undergo ligand-induced conformational changes that facilitate receptor dimerization and subsequent binding to estrogen response elements (EREs) within target gene promoters. This binding enables the recruitment of transcriptional co-regulators?either coactivators or corepressors?thereby modulating gene expression in a context-dependent manner.

Two distinct isoforms of the estrogen receptor exist, ER? and ER?, encoded by ESR1 and ESR2 genes, respectively. ER? binds estrogens with an affinity comparable to that of ER?, yet certain ER? isoforms can exert dominant-negative effects on ER?-mediated transcription, particularly within reproductive tissues. ER? is broadly expressed across a variety of tissues and has been implicated in tumor-suppressive functions. It plays a significant regulatory role in several pathological conditions, including prostate carcinoma, medullary thyroid carcinoma, cardiovascular disease, De Quervain tenosynovitis, and neurodevelopmental disorders such as autism spectrum disorder

Source:
Mouse Monoclonal
Clone:
ERb455
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Nucleus
Positive Control:
Breast Carcinoma
Catalog No.
Volume/Qty.
Format
DH430-3R
3 ml
Ready to Use
DH430-6R
6 ml
Ready to Use
DH430-12R
12 ml
Ready to Use
DH430-01C
0.1 ml
Concentrated
DH430-05C
0.5 ml
Concentrated
DH430-1C
1 ml
Concentrated

ERG

Clone: EP111
Description

ERG belongs to the ETS family that plays important roles in cell development, differentiation, proliferation, apoptosis and tissue remodeling. The aberrant expression of several ETS proteins is involved in tumor development and progression. ERG is linked to normal processes such as mesoderm formation. TMPRSS2-ERG fusion, which occurs on account of translocations and interstitial deletions, is implicated in aggressive forms of prostate cancer. ERG antibody overexpression is associated with aggressive tumor behavior and patient survival in prostate cancer. ERG antibody labels endothelial cells, lymphocytes, and prostate cancer cells.

Source:
Rabbit Monoclonal
Clone:
EP111
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Nucleus
Positive Control:
Prostate, Colon, Kidney, Fallopian Tube, Tonsil, Skin, Brain, Breast
Catalog No.
Volume/Qty.
Format
DH294-3R
3 ml
Ready to Use
DH294-6R
6 ml
Ready to Use
DH294-12R
12 ml
Ready to Use
DH294-01C
0.1 ml
Concentrated
DH294-05C
0.5 ml
Concentrated
DH294-1C
1 ml
Concentrated

ESA (Epithelial Specific Antigen) / EpCAM

Clone: MOC-31
Description

Anti-MOC-31 reacts with a transmembrane glycoprotein present on most glandular epithelium and tumors originating from such epithelium. This antibody has been used to distinguish adenocarcinoma from mesothelioma and hepatocellular carcinoma. This antibody is also useful in distinguishing serous carcinomas of the ovary from mesothelioma.

Source:
Mouse Monoclonal
Clone:
MOC-31
Application:
IHC
Isotype:
IgG1, Kappa
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Adenocarcinomas
Catalog No.
Volume/Qty.
Format
DH154-3R
3 ml
Ready to Use
DH154-6R
6 ml
Ready to Use
DH154-12R
12 ml
Ready to Use
DH154-01C
0.1 ml
Concentrated
DH154-05C
0.5 ml
Concentrated
DH154-1C
1 ml
Concentrated

Estrogen Receptor (ER)

Clone: SP1
Description

Estrogen or Oestrogen Receptor is a nuclear protein and member of the steroid hormone receptor family. ER possesses both DNA binding and ligand binding domains and exerts a significant role in activating the transcription of certain genes. Ligand dependent dimerization and phosphorylation both function to regulate the transcriptional activity of ER. ER content of breast cancer tissue is an important parameter in the prediction of prognosis and response to endocrine therapy. This antibody strongly stains the nucleus of epithelial cells in breast carcinomas. The ER is an important regulator of growth and differentiation in the mammary gland.

Source:
Rabbit Monoclonal
Clone:
SP1
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Nucleus
Positive Control:
Breast Carcinoma
Catalog No.
Volume/Qty.
Format
DH156-3R
3 ml
Ready to Use
DH156-6R
6 ml
Ready to Use
DH156-12R
12 ml
Ready to Use
DH156-01C
0.1 ml
Concentrated
DH156-05C
0.5 ml
Concentrated
DH156-1C
1 ml
Concentrated

Estrogen Receptor-Alpha

Clone: EP1
Description

Estrogen or Oestrogen Receptor-Alpha is a nuclear protein and member of the steroid hormone receptor family. ER-Alpha possesses both DNA binding and ligand binding domains and exerts a significant role in activating the transcription of certain genes.

Ligand dependent dimerization and phosphorylation both function to regulate the transcriptional activity of ER-Alpha

Source:
Rabbit Monoclonal
Clone:
EP1
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Nucleus
Positive Control:
Breast Carcinoma
Catalog No.
Volume/Qty.
Format
DH155-3R
3 ml
Ready to Use
DH155-6R
6 ml
Ready to Use
DH155-12R
12 ml
Ready to Use
DH155-01C
0.1 ml
Concentrated
DH155-05C
0.5 ml
Concentrated
DH155-1C
1 ml
Concentrated
Copyright ©2025 all rights reserved by Dygnova Healthcare Pvt Ltd.
Web Developed by HUNER