Primary Antibodies
Cancer Diagnostics Solutions
Kappa Light Chain
Clone: L1C1
Description
This monoclonal antibody (MAb) specifically targets the kappa light chain of immunoglobulins without cross-reacting with the lambda light chain or any of the five heavy chains. In mammals, the two light chains of an antibody are always identical, consisting of either kappa or lambda chains. Under normal conditions, the kappa-to-lambda ratio is approximately 70:30. However, this balance can be disrupted in cases of multiple myeloma or other B-cell malignancies.
Antibodies against the kappa light chain have been shown to aid in the diagnosis of leukemias, plasmacytomas, and certain types of non-Hodgkin's lymphomas. Additionally, demonstrating clonality in lymphoid infiltrates is a key indicator of malignancy.
Source:
Mouse Monoclonal
Clone:
L1C1
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Tonsil or Spleen
Catalog No.
Volume/Qty.
Format
DH174-3R
3 ml
Ready to Use
DH174-6R
6 ml
Ready to Use
DH174-12R
12 ml
Ready to Use
DH174-01C
0.1 ml
Concentrated
DH174-05C
0.5 ml
Concentrated
DH174-1C
1 ml
Concentrated
Kappa Light Chain
Clone: POLYCLONAL
Description
Kappa detects surface immunoglobulin on normal and neoplastic B-cells. In paraffin-embedded tissue, Kappa exhibits strong staining of kappa-positive plasma cells and cells that have absorbed exogenous immunoglobulin. When studying B-cell neoplasms, the determination of light-chain ratios remains the centerpiece. This is sound reasoning because most B-cell Lymphomas express either Kappa or Lambda light chains, whereas reactive proliferations display a mixture of Kappa and Lambda-positive cells. If only a single light-chain type is detected, a lympho-proliferative disorder is very likely. Monoclonality is determined by a Kappa-Lambda ratio greater than or equal to 3:1, a Lambda-Kappa ratio greater than or equal to 2:1, or a monoclonal population of 75% or more of the total population. In IgG-dominant immune complex-mediated glomerulonephritis, there are multiple pathological findings that strongly suggest the diagnosis of Lupus Nephritis including immunofluorescence staining for IgG, IgM, IgA, Kappa or Lambda, C3 and C1.
Source:
Rabbit Polyclonal
Clone:
POLYCLONAL
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Tonsil, Lymph Node
Catalog No.
Volume/Qty.
Format
DH175-3R
3 ml
Ready to Use
DH175-6R
6 ml
Ready to Use
DH175-12R
12 ml
Ready to Use
DH175-01C
0.1 ml
Concentrated
DH175-05C
0.5 ml
Concentrated
DH175-1C
1 ml
Concentrated
Ki67
Clone: MIB-1
Description
The Ki-67 protein is a nuclear protein doublet, 345-395 kDa, playing a pivotal role in maintaining cell proliferation. In diagnostic histopathology and cell biology, the antibody has proven valuable for the demonstration of the Ki-67 antigen in normal and neoplastic cells, for example in soft-tissue sarcoma, prostatic adenocarcinoma, and breast carcinoma. The Ki-67 has been confirmed as a very powerful single prognostic factor for overall survival, with highly proliferative cases showing a much poorer outcome than tumors with low proliferation. In breast cancer, the proliferative index measured by Ki-67 immunoreactivity has both prognostic and predictive value
Source:
Mouse Monoclonal
Clone:
MIB-1
Application:
IHC
Isotype:
IgG1, Kappa
Tested Reactivity:
Human
Localization:
Nucleus
Positive Control:
Spleen, tonsil, breast carcinomas
Catalog No.
Volume/Qty.
Format
DH176-3R
3 ml
Ready to Use
DH176-6R
6 ml
Ready to Use
DH176-12R
12 ml
Ready to Use
DH176-01C
0.1 ml
Concentrated
DH176-05C
0.5 ml
Concentrated
DH176-1C
1 ml
Concentrated
Ki67
Clone: SP6
Description
Ki-67 is a nuclear protein, which is expressed in proliferating cells. Ki-67 is preferentially expressed during late G1-, S-, M-, and G2-phases of the cell cycle, while cells in the G0 (quiescent) phase are negative for this protein.
Source:
Rabbit Monoclonal
Clone:
SP6
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Nucleus
Positive Control:
Spleen, tonsil, breast carcinomas
Catalog No.
Volume/Qty.
Format
DH177-3R
3 ml
Ready to Use
DH177-6R
6 ml
Ready to Use
DH177-12R
12 ml
Ready to Use
DH177-01C
0.1 ml
Concentrated
DH177-05C
0.5 ml
Concentrated
DH177-1C
1 ml
Concentrated
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