Primary Antibodies
Cancer Diagnostics Solutions
N-Cadherin
Clone: 5D5
Description
N-cadherin is a 140 kDa transmembrane glycoprotein belonging to the cadherin superfamily, which mediates calcium-dependent intercellular adhesion. Cadherins play a pivotal role in regulating morphogenetic movements during embryonic development and modulate cell-cell adhesion through homophilic interactions between identical cadherin molecules. The functional integrity of N-cadherin is contingent upon its linkage to the actin cytoskeleton, facilitated by interactions between its C-terminal cytoplasmic domain and catenin family proteins. The stability of the N-cadherin?catenin complex is dynamically regulated by the phosphorylation and dephosphorylation states of ?-catenin. Structurally, N-cadherin consists of five extracellular cadherin repeats, a single-pass transmembrane domain, and a conserved cytoplasmic tail. Functionally, N-cadherin is essential during gastrulation and contributes to the establishment of embryonic left-right asymmetry
Source:
Mouse Monoclonal
Clone:
5D5
Application:
IHC
Isotype:
IgG1
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Heart and renal carcinoma tissue
Catalog No.
Volume/Qty.
Format
DH576-3R
3 ml
Ready to Use
DH576-6R
6 ml
Ready to Use
DH576-12R
12 ml
Ready to Use
DH576-01C
0.1 ml
Concentrated
DH576-05C
0.5 ml
Concentrated
DH576-1C
1 ml
Concentrated
N-Cadherin
Clone: CDH2/9493
Description
The antibody detects a ~140 kDa protein identified as N-cadherin (CD325), a classical cadherin composed of five extracellular cadherin repeats, a single transmembrane domain, and a cytoplasmic tail mediating cytoskeletal interactions.Genetic loss of CDH2 in mice results in early embryonic lethality with severe cardiac and neural tube malformations, reflecting its essential role in cardiogenesis and embryonic patterning. N-cadherin regulates cell?cell adhesion and growth control and is frequently deregulated in cancer. Upregulation of N-cadherin, often accompanied by loss of E- or P-cadherin (?cadherin switch?), is associated with increased tumor invasiveness and metastatic potential.
Source:
Mouse Monoclonal
Clone:
CDH2/9493
Application:
IHC
Isotype:
IgG2b / Kappa
Tested Reactivity:
Human
Localization:
Membrane,
Positive Control:
Human heart, pancreas or cerebral cortex
Catalog No.
Volume/Qty.
Format
DH629-3R
3 ml
Ready to Use
DH629-6R
6 ml
Ready to Use
DH629-12R
12 ml
Ready to Use
DH629-01C
0.1 ml
Concentrated
DH629-05C
0.5 ml
Concentrated
DH629-1C
1 ml
Concentrated
NANOG
Clone: NANOG/9704
Description
The homeobox protein Nanog is a key transcription factor essential for maintaining the pluripotent state of embryonic stem cells (ESCs) by repressing genes involved in cellular differentiation. In humans, the NANOG gene encodes this regulatory protein. Nanog functions synergistically with other core pluripotency-associated transcription factors such as Oct-4 (POU5F1) and SOX2, collectively establishing and preserving ESC identity. Beyond its physiological role, Nanog is highly expressed in cancer stem cells, implicating it as a potential oncogenic driver involved in tumor initiation and progression. Elevated Nanog expression correlates with poor clinical outcomes and unfavorable prognosis across multiple malignancies.Immunohistochemically, Nanog demonstrates strong and specific nuclear expression in carcinoma in situ (CIS), embryonal carcinomas, and seminomas, while its expression is absent in teratomas and yolk sac tumors. Studies have shown that human embryonic stem cell?related genes, including OCT4, NANOG, STELLAR, and GDF3, are co-expressed in seminomas and certain breast carcinomas. Nanog positivity is prominently observed in high-grade ovarian serous carcinomas, with negligible expression in benign, borderline, or low-grade serous lesions. Additionally, subcellular localization studies have demonstrated cytoplasmic-nuclear shuttling of Nanog and its enhanced stromal expression during cervical carcinogenesis.
Source:
Mouse Monoclonal
Clone:
NANOG/9704
Application:
IHC
Isotype:
IgG2b, Lambda
Tested Reactivity:
Human
Localization:
Nucleus
Positive Control:
Human testicular carcinoma
Catalog No.
Volume/Qty.
Format
DH574-3R
3 ml
Ready to Use
DH574-6R
6 ml
Ready to Use
DH574-12R
12 ml
Ready to Use
DH574-01C
0.1 ml
Concentrated
DH574-05C
0.5 ml
Concentrated
DH574-1C
1 ml
Concentrated
Napsin A
Clone: EP205
Description
The activation peptides of aspartic proteinases play a role as inhibitors of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pro napsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional glycosylated aspartic proteinase precursor containing an RGD motif and an addition 18 residues at its C-terminus.
Source:
Rabbit Monoclonal
Clone:
EP205
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Kidney, Lung, Renal Cell Carcinoma, Lung Carcinoma
Catalog No.
Volume/Qty.
Format
DH197-3R
3 ml
Ready to Use
DH197-6R
6 ml
Ready to Use
DH197-12R
12 ml
Ready to Use
DH197-01C
0.1 ml
Concentrated
DH197-05C
0.5 ml
Concentrated
DH197-1C
1 ml
Concentrated
NELL1
Clone: Polyclonal
Description
This gene encodes a cytoplasmic protein characterized by the presence of epidermal growth factor (EGF)-like repeat domains. The gene product forms part of a heterotrimeric protein complex and is implicated in the regulation of cellular proliferation and differentiation. The homologous protein in rodent models has been shown to play a role in craniosynostosis. Alternative splicing of this gene gives rise to at least two transcript variants that encode distinct protein isoforms
Source:
Rabbit Monoclonal
Clone:
Polyclonal
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Kidney And Liver
Catalog No.
Volume/Qty.
Format
DH618-3R
3 ml
Ready to Use
DH618-6R
6 ml
Ready to Use
DH618-12R
12 ml
Ready to Use
DH618-01C
0.1 ml
Concentrated
DH618-05C
0.5 ml
Concentrated
DH618-1C
1 ml
Concentrated
Neu-N
Clone: NEUN/7071
Description
NeuN antibody specifically recognizes the DNA-binding, neuron-specific protein NeuN, which is present in most CNS and PNS neuronal cell types of all vertebrates tested. NeuN protein distributions are apparently restricted to neuronal nuclei and some proximal neuronal processes in both fetal and adult brain although, some neurons fail to be recognized by NeuN at all ages: INL retinal cells, Cajal-Retzius cells, Purkinje cells, inferior olivary and dentate nucleus neurons, and sympathetic ganglion cells are examples. Immunohistochemically detectable NeuN protein first appears at developmental timepoints that correspond with the withdrawal of the neuron from the cell cycle and/or with the initiation of terminal differentiation of the neuro.
Immunoreactivity appears around E9.5 in the Rabbit neural tube and is extensive throughout the developing nervous system by E12.5. Strong nuclear staining suggests a nuclear regulatory protein function; however, no evidence currently exists as to whether the NeuN protein antigen has a function in the distal cytoplasm or whether it is merely synthesized there before being transported back into the nucleus. No difference between protein isolated from purified nuclei and whole brain extract on immunoblots has been found.
Source:
Rabbit Monoclonal
Clone:
NEUN/7071
Application:
IHC
Isotype:
IgG, kappa
Tested Reactivity:
Human
Localization:
Cytoplasm, Nucleus
Positive Control:
Human Brain tissue.
Catalog No.
Volume/Qty.
Format
DH418-3R
3 ml
Ready to Use
DH418-6R
6 ml
Ready to Use
DH418-12R
12 ml
Ready to Use
DH418-01C
0.1 ml
Concentrated
DH418-05C
0.5 ml
Concentrated
DH418-1C
1 ml
Concentrated
Neu-N
Clone: A60
Description
NeuN, also known as Fox-3 (Feminizing Locus on X-3) or hexaribonucleotide-binding protein-3, is a neuron-specific nuclear protein expressed in the majority of neuronal populations within both the central nervous system (CNS) and peripheral nervous system (PNS). The spatial distribution of NeuN is predominantly nuclear, with additional localization to the neuronal perikaryon and select proximal neuronal processes, and this pattern is maintained in both fetal and adult neural tissues. Notably, certain neuronal subtypes consistently lack detectable NeuN expression across developmental stages, including inner nuclear layer (INL) retinal neurons, Cajal?Retzius cells, and Purkinje cells of the cerebellum, neurons of the inferior olivary and dentate nuclei, and sympathetic ganglion cells.Owing to its robust and selective expression in mature neurons, NeuN immunohistochemistry is extensively employed as a pan-neuronal marker. NeuN immunoreactivity typically emerges during neuronal maturation and differentiation, becoming prominent after the downregulation of Doublecortin, a microtubule-associated protein expressed during early neuronal development and migration. Consequently, NeuN serves as a reliable marker for post-mitotic, differentiated neurons in both developmental and neuropathological studies.
Source:
Mouse Monoclonal
Clone:
A60
Application:
IHC
Isotype:
IgG2
Tested Reactivity:
Human
Localization:
Nuclear
Positive Control:
Brain
Catalog No.
Volume/Qty.
Format
DH606-3R
3 ml
Ready to Use
DH606-6R
6 ml
Ready to Use
DH606-12R
12 ml
Ready to Use
DH606-01C
0.1 ml
Concentrated
DH606-05C
0.5 ml
Concentrated
DH606-1C
1 ml
Concentrated
Neurofilaments
Clone: NE14
Description
This monoclonal antibody recognizes a 200 kDa protein corresponding to the heavy subunit of neurofilaments (NF-H). Its reactivity is specific to the phosphorylated KSP/KEP repeat domain located at the C-terminal region of NF-H. Following dephosphorylation of neurofilaments with alkaline phosphatase, antibody binding is abrogated, confirming phosphorylation-dependent recognition. Neurofilaments constitute the principal structural scaffolding of axons and dendrites and are distributed throughout neurons, peripheral nerves, and sympathetic ganglion cells. They are composed of three major subunits: NF-L (68 kDa), NF-M (160 kDa), and NF-H (200 kDa). Immunoreactivity with anti-neurofilament is observed across a spectrum of neural, neuroendocrine, and endocrine neoplasms. Positive staining is typically seen in neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas, and neuroblastomas. Additionally, neurofilament expression is detected in paragangliomas, as well as in adrenal and extra-adrenal pheochromocytomas. Carcinoid tumors, cutaneous neuroendocrine carcinomas, and pulmonary small-cell (oat cell) carcinomas also demonstrate immunopositivity for neurofilament
Source:
Mouse Monoclonal
Clone:
NE14
Application:
IHC
Isotype:
IgG1, Kappa
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Neuroblastoma.
Catalog No.
Volume/Qty.
Format
DH551-3R
3 ml
Ready to Use
DH551-6R
6 ml
Ready to Use
DH551-12R
12 ml
Ready to Use
DH551-01C
0.1 ml
Concentrated
DH551-05C
0.5 ml
Concentrated
DH551-1C
1 ml
Concentrated
NKX2.2
Clone: NX2/294
Description
The protein encoded by this gene possesses a homeobox domain, suggesting a regulatory role in developmental processes, particularly in the morphogenesis of the central nervous system. The gene is localized on chromosome 20 in close proximity to NKX2-4, with both genes exhibiting paralogous duplication on chromosome 14, giving rise to TITF1 (NKX2-1) and NKX2-8. The encoded protein is presumed to function as a nuclear transcription factor, participating in the modulation of gene expression during embryonic development
Source:
Mouse Monoclonal
Clone:
NX2/294
Application:
IHC
Isotype:
IgG2b, kappa
Tested Reactivity:
Human
Localization:
Nucleus
Positive Control:
Pancreas, Ewings Sarcoma
Catalog No.
Volume/Qty.
Format
DH417-3R
3 ml
Ready to Use
DH417-6R
6 ml
Ready to Use
DH417-12R
12 ml
Ready to Use
DH417-01C
0.1 ml
Concentrated
DH417-05C
0.5 ml
Concentrated
DH417-1C
1 ml
Concentrated
NKX2.2
Clone: EP336
Description
Homeobox protein NKX2.2, encoded by the NKX2-2 gene, is a transcription factor crucial for neuroendocrine and glial differentiation, expressed in the developing forebrain and spinal cord. It is significant in neuronal development and fate specification.
NKX2.2 is a valuable marker for Ewing's sarcoma, showing strong correlation with the EWS-FLI transcription factor, a common aberration in 85% of cases. Unlike CD99, which is nonspecific and also expressed in various cells and tumors, NKX2.2 specifically labels 93% of Ewing?s sarcoma cases and only a few non-Ewing tumors, aiding in differential diagnosis with high sensitivity and specificity
Source:
Rabbit Monoclonal
Clone:
EP336
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Nucleus
Positive Control:
Pancreas, Brain, Pituitary, Colon
Catalog No.
Volume/Qty.
Format
DH299-3R
3 ml
Ready to Use
DH299-6R
6 ml
Ready to Use
DH299-12R
12 ml
Ready to Use
DH299-01C
0.1 ml
Concentrated
DH299-05C
0.5 ml
Concentrated
DH299-1C
1 ml
Concentrated
NKX3.1
Clone: EP356
Description
Homeobox protein NKX3.1, also known as BAPX2 and NKX3A is a protein that in humans is encoded by the NKX3.1 gene located on chromosome 8p. NKX3.1 is a prostatic tumor suppressor gene, which is an androgen-regulated, prostate-specific homeobox gene whose expression is predominantly localized in the prostate epithelium. It is a negative regulator of epithelial cell growth in prostate tissue. Loss of NKX3A protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia. NKX3-1 expression is seen in prostate epithelium, testis, ureter, and pulmonary bronchial mucous glands. NKX3-1 has been established as a marker for identifying metastatic tumors. In a study the sensitivity for identifying metastatic Prostatic Adenocarcinomas was 98.6% for NKX3.1, 94.2% for PSA and 98.6% for PSAP and specificity of 99.7% for NKX3.1. NKX3.1-positive prostate carcinoma cells exhibit nuclear staining. Additionally, most cases of Urothelial Carcinoma have been found to be negative for NKX3.1 and may be helpful to distinguish between high grade Prostate Adenocarcinoma and high grade Infiltrating Urothelial Carcinoma. NKX3.1 has also been found to be expressed in Invasive Ductal Carcinomas (IDC) and Invasive Lobular Carcinomas (ILC) of the breast. NKX3.1 expression is limited to ER, PR, and AR positive carcinomas and is more frequently expressed in ILC than IDC. NKX3.1 has a high specificity and sensitivity for prostate adenocarcinomas and can be used to help distinguish between Prostate Carcinoma and Urothelial Carcinomas
Source:
Rabbit Monoclonal
Clone:
EP356
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Nucleus
Positive Control:
Prostate, Prostate Carcinoma
Catalog No.
Volume/Qty.
Format
DH198-3R
3 ml
Ready to Use
DH198-6R
6 ml
Ready to Use
DH198-12R
12 ml
Ready to Use
DH198-01C
0.1 ml
Concentrated
DH198-05C
0.5 ml
Concentrated
DH198-1C
1 ml
Concentrated
NKX6.1
Clone: NKX61/2561
Description
Members of the NKX family are homeobox transcription factors essential for tissue patterning and differentiation in the CNS, heart, and pancreas. During neural development, SHH signaling induces dose-dependent expression of NKX6.1, which mediates ventral neural tube differentiation. In the pancreas, NKX6.1 is selectively expressed in insulin-producing ? cells of the islets of Langerhans in a PDX1-dependent manner and regulates ?-cell gene programs through binding to the consensus sequence TTAATTAC.Immunohistochemically, NKX6.1 is highly expressed in pancreatic and duodenal well-differentiated neuroendocrine tumors, including metastases, and serves as a specific marker of pancreatic origin, supporting its inclusion in IHC panels for WDNET primary site assignment.
Source:
Mouse Monoclonal
Clone:
NKX61/2561
Application:
IHC
Isotype:
IgG2c / Kappa
Tested Reactivity:
Human
Localization:
Nucleus
Positive Control:
Human fetal small intestine lysate or pancreas
Catalog No.
Volume/Qty.
Format
DH631-3R
3 ml
Ready to Use
DH631-6R
6 ml
Ready to Use
DH631-12R
12 ml
Ready to Use
DH631-01C
0.1 ml
Concentrated
DH631-05C
0.5 ml
Concentrated
DH631-1C
1 ml
Concentrated
Notch 1
Clone: A-8
Description
The LIN-12/Notch family of transmembrane receptors plays a pivotal role in developmental processes by governing cell fate determination. In mammals, four Notch homologs?Notch1, Notch2, Notch3, and Notch4?have been identified. These genes exhibit broad expression across embryonic and adult tissues, indicating participation in diverse and context-dependent signaling cascades. Aberrant Notch signaling, including receptor overexpression or genomic rearrangements, has been documented in a range of human malignancies. Canonical ligands of the Notch receptors include Jagged1, Jagged2, and Delta. Jagged1 functions as an activator of Notch signaling and inhibits myogenic differentiation by suppressing the transcription of muscle-specific regulatory and structural genes. Jagged2 is implicated in developmental processes that rely on epithelial?mesenchymal interactions. Delta is normally expressed in tissues such as the adrenal gland and placenta, but its expression has also been observed in neuroendocrine tumors, suggesting a potential role in tumor-associated Notch signaling dysregulation
Source:
Mouse Monoclonal
Clone:
A-8
Application:
IHC
Isotype:
IgM
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Urinary Bladder
Catalog No.
Volume/Qty.
Format
DH581-3R
3 ml
Ready to Use
DH581-6R
6 ml
Ready to Use
DH581-12R
12 ml
Ready to Use
DH581-01C
0.1 ml
Concentrated
DH581-05C
0.5 ml
Concentrated
DH581-1C
1 ml
Concentrated
NSE
Clone: ENO2/8614
Description
This monoclonal antibody targets a protein of approximately 50 kDa, identified as gamma-enolase. There are three isoenzymes of enolase: alpha, beta, and gamma. The alpha isoform is expressed in most tissues, while the beta isoform is primarily found in muscle tissue. In contrast, gamma-enolase is exclusively present in nervous tissue.
These isoforms can form both homodimers and heterodimers and are involved in the glycolytic pathway, specifically in converting phosphoglyceric acid to phosphoenolpyruvic acid. Gamma-enolase (NSE) serves as a valuable marker for identifying peripheral nerves and neuroendocrine tumors, such as pheochromocytomas. It is typically used in combination with other markers, including Synaptophysin, Chromogranin A, and Neurofilament
Source:
Mouse Monoclonal
Clone:
ENO2/8614
Application:
IHC
Isotype:
IgG1, Kappa
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Cerebellum or Pheochromocytoma, Human pancreas.
Catalog No.
Volume/Qty.
Format
DH199-3R
3 ml
Ready to Use
DH199-6R
6 ml
Ready to Use
DH199-12R
12 ml
Ready to Use
DH199-01C
0.1 ml
Concentrated
DH199-05C
0.5 ml
Concentrated
DH199-1C
1 ml
Concentrated
NSE (Neuron Specific Enolase)
Clone: MRQ-55
Description
Neuron-specific enolase (NSE) is a gamma-gamma isoform of the glycolytic enzyme enolase, selectively expressed in neurons, peripheral nerves, and various neuroendocrine cells and neoplasms. It serves as a reliable marker for neural and neuroendocrine differentiation due to its high tissue specificity. While its expression is predominantly neuronal, low-level immunoreactivity may also be observed in smooth muscle tissue. Immunohistochemical detection of NSE is frequently employed to visualize peripheral nerve structures and to support the diagnosis of tumors exhibiting neuroendocrine differentiation, including neuroblastomas, small cell carcinomas, and pheochromocytomas.
Source:
Mouse Monoclonal
Clone:
MRQ-55
Application:
IHC
Isotype:
IgG
Tested Reactivity:
Human
Localization:
Cytoplasm
Positive Control:
Carcinoid tumor
Catalog No.
Volume/Qty.
Format
DH519-3R
3 ml
Ready to Use
DH519-6R
6 ml
Ready to Use
DH519-12R
12 ml
Ready to Use
DH519-01C
0.1 ml
Concentrated
DH519-05C
0.5 ml
Concentrated
DH519-1C
1 ml
Concentrated
NUT1
Clone: SNUPN/7363
Description
NUTM1 (NUT Midline Carcinoma Family Member 1) is a protein-coding gene implicated in aggressive malignancies such as NUT midline carcinoma and spindle cell sarcoma. It is involved in chromatin remodeling and transcriptional regulation, particularly within the context of histone acetylation pathways. NUTM1 contributes to the control of cellular proliferation and has been shown to regulate TERT (telomerase reverse transcriptase) expression by modulating the binding affinity of the transcription factor SP1 to specific sites within the TERT promoter. A known paralog of NUTM1 is NUTM2G, which may share functional similarities.
Source:
Rabbit Monoclonal
Clone:
SNUPN/7363
Application:
IHC
Isotype:
IgG, kappa
Tested Reactivity:
Human
Localization:
Cytoplasm, Nucleus
Positive Control:
Human testis.
Catalog No.
Volume/Qty.
Format
DH416-3R
3 ml
Ready to Use
DH416-6R
6 ml
Ready to Use
DH416-12R
12 ml
Ready to Use
DH416-01C
0.1 ml
Concentrated
DH416-05C
0.5 ml
Concentrated
DH416-1C
1 ml
Concentrated
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